The R&B singer claimed three trophies for 'Best Female', 'Best Song' for 'Halo' and 'Best Video' for 'Single Ladies (Put a Ring On It)', while U2 won the Best Live Act award, reported Contactmusic.
The Irish rockers also performed a six-song mini-gig in front of 10,000 fans at the German capital's iconic Brandenburg Gate on Thursday night, as part of the awards' return to Berlin for the first time in 15 years.
'Paparazzi' hitmaker Lady Gaga took away the 'Best New Act' trophy, while rapper Eminem beat Jay-Z and Kanye West to claim the 'Best Male' trophy.
Rock band Green Day were also big winners, scoring the night's 'Best Rock Act' award at the ceremony which had performances by Shakira, Leona Lewis, Tokio Hotel and Knowles with her husband Jay-Z.
Singer Katy Perry thrilled the crowd during her second stint as host at the MTV EMAs, changing outfits a staggering 12 times and paying homage to actress Liza Minnelli in German-based wartime movie classic 'Cabaret' with a raunchy medley of tracks by Lady GaGa, Kings of Leon, Black Eyed Peas and David Guetta.
